Henry G. Grabowski

Henry G. Grabowski

Professor Emeritus of Economics

External Address: 
314 Social Sciences, Durham, NC 27708
Internal Office Address: 
Box 90097, Durham, NC 27708-0097
(919) 660-1839

Professor Grabowski specializes in the investigation of economics in the pharmaceutical industry, government regulation of business, and the economics of innovation. His specific interests within these fields include intellectual property and generic competition issues, the effects of government policy actions, and the costs and returns to pharmaceutical R&D. He has been publishing research papers for over four decades, from his earlier work, “The Effects of Regulatory Policy on the Incentives to Innovate: An International Comparative Analysis” with John Vernon and Lacy Glenn Thomas, to his more recent projects including, “Impact of Economic, Regulatory and Patent Policies on Innovation in Cancer Chemoprevention” with Jeffrey L. Moe. His latest research studies include other such titles as, “Mergers and Alliances in Pharmaceuticals: Effects on Innovation and R&D Productivity” with Margaret Kyle; “Should the Patent System for New Medicines Be Abolished?” with J.A. DiMasi; and several others. Professor Grabowski has served as an advisor and consultant to various organizations, offering his ideas and insights gained through his extensive investigations to the National Trade Academy of Sciences, the Institute of Medicine, the Office of Technology Assessment, the Federal Trade Commission, and the General Accounting Office. His latest project involved an analysis for the FTC concerning public policy, competition and investment in the “Next Generation of Biologics.”


  • Ph.D., Princeton University 1967
  • M.A., Princeton University 1964
  • B.S., Lehigh University 1962

Grabowski, HG, Marriott, Z, Kovacheva, P, and Elzinga, A. "One Year after the Launch of the First U.S. Biosimilar Drug: Lessons for the Future?." (August 9, 2017).

Skinner, MW, Hedlund Hoppe, PA, Grabowski, HG, Manning, R, Tachdjian, R, Crone, JF, and Youngner, SJ. "Risk-based decision making and ethical considerations in donor compensation for plasma-derived medicinal products." Transfusion 56, no. 11 (November 2016): 2889-2894. Full Text Open Access Copy

Grabowski, H, Long, G, Mortimer, R, and Boyo, A. "Updated trends in US brand-name and generic drug competition." Journal of Medical Economics 19, no. 9 (September 2016): 836-844. Full Text Open Access Copy

Grabowski, HG, and Manning, RL. "An Economic Analysis of Global Policy Proposals to Prohibit Compensation of Blood Plasma Donors." International Journal of the Economics of Business 23, no. 2 (May 3, 2016): 149-166. Full Text Open Access Copy

DiMasi, JA, Grabowski, HG, and Hansen, RW. "Innovation in the pharmaceutical industry: New estimates of R&D costs." Journal of Health Economics 47 (May 2016): 20-33. Full Text Open Access Copy

Lietzan, EF, and Grabowski, HG. "FDA Regulation of Biosimilars." (September 16, 2015).

DiMasi, JA, Grabowski, HG, and Hansen, RW. "The cost of drug development." The New England journal of medicine 372, no. 20 (May 2015): 1972-. (Letter) Full Text Open Access Copy

Grabowski, HG, DiMasi, JA, and Long, G. "The roles of patents and research and development incentives in biopharmaceutical innovation." Health Affairs (Project Hope) 34, no. 2 (February 2015): 302-310. Full Text Open Access Copy

Grabowski, HG, Guha, R, and Salgado, M. "Regulatory and cost barriers are likely to limit biosimilar development and expected savings in the near future." Health affairs (Project Hope) 33, no. 6 (June 2014): 1048-1057. Full Text Open Access Copy

Grabowski, H, Guha, R, and Salgado, M. "Biosimilar competition: lessons from Europe." Nature Reviews Drug Discovery 13, no. 2 (February 2014): 99-100. Full Text Open Access Copy


Grabowski, HG. "FDA in the Twenty-First Century." In FDA Regulation Of Biosimilars,edited by G Cohen, and H Lynch, 414-430. Columbia University Press, 2015. (Chapter) Open Access Copy

Grabowski, HG, Long, G, and Mortiner, R. "Biosimilars." In Encyclopedia of Health Economics,edited by A Culyer. Elsevier, 2014. (Chapter)

DiMasi, JA, and Grabowski, HG. "R&D Costs and Returns to New Drug Development: A Review of the Evidence." In The Oxford Handbook of the Economics of the Biopharmaceutical Industry. September 18, 2012. Full Text Open Access Copy

Grabowski, HG. "The Contribution of the United States, Europe and Japan in Discovering New Drugs: 1982-2003." In Incentives for Research, Development, and Innovation in Pharmaceuticals,edited by WA Garcia-Fontes, 49-68. Springer, August 9, 2012. Open Access Copy

Grabowski, HG, and Kyle, M. "Mergers, Acquisitions, and Alliances.".: Oxford University Press, April 24, 2012. Full Text Open Access Copy

Grabowski, HG, Ridley, David B., , Moe, and Jeffrey L., . "Encouraging innovative treatment of neglected diseases through priority review vouchers." In Prescribing Cultures and Pharmaceutical Policy in the Asia-Pacific,edited by K Eggleston, 347-365. Stanford, CA: Stanford University: The Walter H, Shorenstein Asia-Pacific Research Center, September 1, 2009. Open Access Copy

Grabowski, HG, and Kyle, M. "Mergers and Alliances in Pharmaceutical: Effects on Innovation and R&D Productivity." In The Economics of Corporate Governance and Mergers,edited by K Gugler and B Yurtoglu, 262-287. Cheltenham, UK; USA: Edward Elgar Publishing, January 1, 2008. Open Access Copy

Grabowski, HG. "Competition between Generic and Branded Drugs." In Pharmaceutical innovation: incentives, competition, and cost-benefit analysis in international perspective,edited by FA Sloan and C-R Hsieh, 153-288. Cambridge; New York: Cambridge University Press, April 30, 2007. Open Access Copy

Grabowski, HG. "Increasing R&D Incentives for Neglected Diseases: Lessons from the Orphan Drug Act." In International Public Goods And Transfer Of Technology Under A Globalized Intellectual Property Regime,edited by KKE Maskus and JJH Reichman, 457-480. 2005. Open Access Copy

Grabowski, HG. "Increasing R&D incentives for neglected diseases: Lessons from the Orphan Drug Act." In International Public Goods And Transfer Of Technology Under A Globalized Intellectual Property Regime,edited by KKE Maskus and JJH Reichman, 457-480. Cambridge, UK, New York: Cambridge University Press, 2005. Open Access Copy


Grabowski, HG. "Pharmaceuticals and Health Care Costs." International Health Care Forum. Gotemba, Japan. October 1, 1992. Open Access Copy